Cutting tool design knowledge capture ;reuse

Cutting tools play an important part in today's manufacturing industry. There is an ever-increasing pressure on the cutting tool design industry to produce better quality products in response to the needs of the automotive and aerospace industries. Add to this the increasing complexity of the machined product requiring the use of non-standard cutting tools. The consideration of this area of cutting tool design is in recognition of the importance of the information and knowledge requirements at the beginning and during the design process. It has been noticed that in the cutting tool industry that the knowledge provision lacks structure and organisation. Understanding the knowledge requirements of the designers would provide substantial benefits to the design process. Thus, this research explores the role and extent of special purpose cutting tool design knowledge. Literature review shows there is a lack of research examining the knowledge of designers within special purpose cutting tool design. The design of a special purpose-cutting tool is a knowledge intensive task. This thesis presents a novel methodology for Knowledge Elicitation called Knowledge = Expert - Novice (KEN). KEN is a methodology requiring active participation in the design task. It is demonstrated that KEN is suitable for the capture of cutting tool design knowledge. KEN is used to examine the nature and extent of special purpose cutting tool design. It is observed that KEN provides a structured approach to the Knowledge Elicitation from an expert. An in-depth investigation of the preliminary design stage has revealed the knowledge required by special purpose cutting tool designers. This thesis presents an ontology-based framework for cutting tool design knowledge representation following a functional, structural and behavioural methodology. The knowledge is represented by base-functions, ways of achievement and design considerations organised into functional hierarchies. The ontology is validated by domain experts rating the terms within the ontology and by cases. It is observed that the ontology is a complete representation of the cutting tool design knowledge. A viewpoint of design reuse is modelled to include a set of descriptor terms and captured domain knowledge. The viewpoint is mapped onto the ontology to provide a set of generic terms. The reuse viewpoint is then implemented onto Case-Based Reasoning software to search for past designs. The reuse viewpoint is then validated using a number of case studies and user trials. It is demonstrated that the reuse viewpoint is effective for the extraction of terms from design documentation, searching for and recalling past designs.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

2017 Research & Innovation Day Program

A one day showcase of applied research, social innovation, scholarship projects and activities.https://first.fanshawec.ca/cri_cripublications/1004/thumbnail.jp

Antibodies against endogenous retroviruses promote lung cancer immunotherapy

B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS). Although TLS have been found to correlate with improved patient survival and response to immune checkpoint blockade (ICB), the underlying mechanisms of this association remain elusive. Here we investigate lung-resident B cell responses in patients from the TRACERx 421 (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy) and other lung cancer cohorts, and in a recently established immunogenic mouse model for lung adenocarcinoma. We find that both human and mouse lung adenocarcinomas elicit local germinal centre responses and tumour-binding antibodies, and further identify endogenous retrovirus (ERV) envelope glycoproteins as a dominant anti-tumour antibody target. ERV-targeting B cell responses are amplified by ICB in both humans and mice, and by targeted inhibition of KRAS(G12C) in the mouse model. ERV-reactive antibodies exert anti-tumour activity that extends survival in the mouse model, and ERV expression predicts the outcome of ICB in human lung adenocarcinoma. Finally, we find that effective immunotherapy in the mouse model requires CXCL13-dependent TLS formation. Conversely, therapeutic CXCL13 treatment potentiates anti-tumour immunity and synergizes with ICB. Our findings provide a possible mechanistic basis for the association of TLS with immunotherapy response

Cutting Tool Design Knowledge Capture & Reuse

Cutting tools play an important part in today's manufacturing industry. There is an ever-increasing pressure on the cutting tool design industry to produce better quality products in response to the needs of the automotive and aerospace industries. Add to this the increasing complexity of the machined product requiring the use of non-standard cutting tools. The consideration of this area of cutting tool design is in recognition of the importance of the information and knowledge requirements at the beginning and during the design process. It has been noticed that in the cutting tool industry that the knowledge provision lacks structure and organisation. Understanding the knowledge requirements of the designers would provide substantial benefits to the design process. Thus, this research explores the role and extent of special purpose cutting tool design knowledge. Literature review shows there is a lack of research examining the knowledge of designers within special purpose cutting tool design. The design of a special purpose-cutting tool is a knowledge intensive task. This thesis presents a novel methodology for Knowledge Elicitation called Knowledge = Expert - Novice (KEN). KEN is a methodology requiring active participation in the design task. It is demonstrated that KEN is suitable for the capture of cutting tool design knowledge. KEN is used to examine the nature and extent of special purpose cutting tool design. It is observed that KEN provides a structured approach to the Knowledge Elicitation from an expert. An in-depth investigation of the preliminary design stage has revealed the knowledge required by special purpose cutting tool designers. This thesis presents an ontology-based framework for cutting tool design knowledge representation following a functional, structural and behavioural methodology. The knowledge is represented by base-functions, ways of achievement and design considerations organised into functional hierarchies. The ontology is validated by domain experts rating the terms within the ontology and by cases. It is observed that the ontology is a complete representation of the cutting tool design knowledge. A viewpoint of design reuse is modelled to include a set of descriptor terms and captured domain knowledge. The viewpoint is mapped onto the ontology to provide a set of generic terms. The reuse viewpoint is then implemented onto Case-Based Reasoning software to search for past designs. The reuse viewpoint is then validated using a number of case studies and user trials. It is demonstrated that the reuse viewpoint is effective for the extraction of terms from design documentation, searching for and recalling past designs

Cutting tool design knowledge capture and reuse

Available from British Library Document Supply Centre- DSC:DXN064217 / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

The scientific rationale for deployment of a long-lived geophysical network on the Moon

International audienc

The International Linear Collider: Report to Snowmass 2021

International audienceThe International Linear Collider (ILC) is on the table now as a new global energy-frontier accelerator laboratory taking data in the 2030s. The ILC addresses key questions for our current understanding of particle physics. It is based on a proven accelerator technology. Its experiments will challenge the Standard Model of particle physics and will provide a new window to look beyond it. This document brings the story of the ILC up to date, emphasizing its strong physics motivation, its readiness for construction, and the opportunity it presents to the US and the global particle physics community

The International Linear Collider: Report to Snowmass 2021

The International Linear Collider (ILC) is on the table now as a new global energy-frontier accelerator laboratory taking data in the 2030s. The ILC addresses key questions for our current understanding of particle physics. It is based on a proven accelerator technology. Its experiments will challenge the Standard Model of particle physics and will provide a new window to look beyond it. This document brings the story of the ILC up to date, emphasizing its strong physics motivation, its readiness for construction, and the opportunity it presents to the US and the global particle physics community

The International Linear Collider: Report to Snowmass 2021

International audienceThe International Linear Collider (ILC) is on the table now as a new global energy-frontier accelerator laboratory taking data in the 2030s. The ILC addresses key questions for our current understanding of particle physics. It is based on a proven accelerator technology. Its experiments will challenge the Standard Model of particle physics and will provide a new window to look beyond it. This document brings the story of the ILC up to date, emphasizing its strong physics motivation, its readiness for construction, and the opportunity it presents to the US and the global particle physics community